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- Title
Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors.
- Authors
Zanoni, Ivan; Granucci, Francesca
- Abstract
Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
- Publication
Journal of molecular medicine (Berlin, Germany), 2010, Vol 88, Issue 9, p873
- ISSN
1432-1440
- Publication type
Journal Article
- DOI
10.1007/s00109-010-0638-x