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- Title
How to halve ploidy: lessons from budding yeast meiosis.
- Authors
Kerr, Gary William; Sarkar, Sourav; Arumugam, Prakash
- Abstract
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.
- Publication
Cellular and molecular life sciences : CMLS, 2012, Vol 69, Issue 18, p3037
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-012-0974-9