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- Title
The role of HLA-G in immunity and hematopoiesis.
- Authors
Carosella, Edgardo D; Gregori, Silvia; Rouas-Freiss, Nathalie; LeMaoult, Joel; Menier, Catherine; Favier, Benoit
- Abstract
The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.
- Publication
Cellular and molecular life sciences : CMLS, 2011, Vol 68, Issue 3, p353
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-010-0579-0