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- Title
Dengue virus life cycle: viral and host factors modulating infectivity.
- Authors
Rodenhuis-Zybert, Izabela A; Wilschut, Jan; Smit, Jolanda M
- Abstract
Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.
- Publication
Cellular and molecular life sciences : CMLS, 2010, Vol 67, Issue 16, p2773
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-010-0357-z