We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nuclear transport and the mitotic apparatus: an evolving relationship.
- Authors
Wozniak, Richard; Burke, Brian; Doye, Valérie
- Abstract
The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs) and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target compartment. While their functions in transport are well established, an ever-growing number of observations have also linked components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression.
- Publication
Cellular and molecular life sciences : CMLS, 2010, Vol 67, Issue 13, p2215
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-010-0325-7