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- Title
Myosin motor function: the ins and outs of actin-based membrane protrusions.
- Authors
Nambiar, Rajalakshmi; McConnell, Russell E; Tyska, Matthew J
- Abstract
Cells build plasma membrane protrusions supported by parallel bundles of F-actin to enable a wide variety of biological functions, ranging from motility to host defense. Filopodia, microvilli and stereocilia are three such protrusions that have been the focus of intense biological and biophysical investigation in recent years. While it is evident that actin dynamics play a significant role in the formation of these organelles, members of the myosin superfamily have also been implicated as key players in the maintenance of protrusion architecture and function. Based on a simple analysis of the physical forces that control protrusion formation and morphology, as well as our review of available data, we propose that myosins play two general roles within these structures: (1) as cargo transporters to move critical regulatory components toward distal tips and (2) as mediators of membrane-cytoskeleton adhesion.
- Publication
Cellular and molecular life sciences : CMLS, 2010, Vol 67, Issue 8, p1239
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-009-0254-5