We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The p200 family protein p204 as a modulator of cell proliferation and differentiation: a brief survey.
- Authors
Lengyel, Peter; Liu, C J
- Abstract
The expression of the murine p200 family protein p204 in numerous tissues can be activated by a variety of distinct, tissue-specific transcription factors. p204 modulates cell proliferation, cell cycling, and the differentiation of various tissues, including skeletal muscle myotubes, beating cardiac myocytes, osteoblasts, chondrocytes, and macrophages. This protein modulates these processes in various ways, such as by (1) blocking ribosomal RNA synthesis in the nucleolus, (2) inhibiting Ras signaling in the cytoplasm, (3) promoting the activity of particular transcription factors in the nucleus by forming complexes with them, and (4) overcoming the block of the activity of other transcription factors by inhibitor of differentiation (Id) proteins. Much remains to be learned about p204, particularly with respect to its expected involvement in the differentiation of several as yet unexplored tissues.
- Publication
Cellular and molecular life sciences : CMLS, 2010, Vol 67, Issue 3, p335
- ISSN
1420-9071
- Publication type
Journal Article
- DOI
10.1007/s00018-009-0195-z