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- Title
Galanin, galanin receptors and drug targets.
- Authors
Mitsukawa, K; Lu, X; Bartfai, T
- Abstract
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Over the past decade, some of the receptor subtype-specific effects have been elucidated through pharmacological studies using subtype selective ligands, as well as through molecular approaches involving knockout animals. In the present review, we summarize the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
- Publication
Cellular and molecular life sciences : CMLS, 2008, Vol 65, Issue 12, p1796
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-008-8153-8