We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structural studies of elongation and release factors.
- Authors
Noble, C G; Song, H
- Abstract
The elongation and termination steps of protein synthesis are controlled by elongation and release factors, respectively. Elongation factors deliver the aminoacyl tRNA to the ribosomal A site, ensuring the elongation of the nascent polypeptide chain by one amino acid at a time, while release factors recognize the stop codons and trigger the release of the polypeptide from the ribosome. Recently, high-resolution crystal structures of ribosomes as well as translation factors on and off the ribosome have contributed a great deal to our understanding of the molecular basis of protein synthesis. This review concentrates on recent developments in our understanding of the elongation and termination steps of protein synthesis, particularly the roles of translation factors and their similarities and differences in the eukaryotic cytosol and prokaryotic systems, through a combination of structural and biochemical studies.
- Publication
Cellular and molecular life sciences : CMLS, 2008, Vol 65, Issue 9, p1335
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-008-7495-6