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- Title
Re-creating an RNA world.
- Authors
Müller, U F
- Abstract
The RNA world hypothesis states that life originated via a system based on RNA genomes and RNA catalysts. Researchers have been trying to develop such a system since catalytic RNAs (ribozymes) were discovered in 1982. This review summarizes the recent progress made in that endeavor and outlines the obstacles that remain to be overcome. After giving a short background on prebiotic chemistry and in vitro evolution, the discussion focuses on the generation of three important components of an RNA world: a sufficient polymerase ribozyme, self-replicating membrane compartments and ribozymes that are capable of performing basic metabolic processes.
- Publication
Cellular and molecular life sciences : CMLS, 2006, Vol 63, Issue 11, p1278
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-006-6047-1