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- Title
Nodal signals pattern vertebrate embryos.
- Authors
Tian, T; Meng, A M
- Abstract
Vertebrate embryonic patterning requires several conserved inductive signals-including Nodal, Bmp, Wnt and Fgf signals. Nodal, which is a member of the transforming growth factor beta (TGFbeta) superfamily, activates a signal transduction pathway that is similar to that of other TGFbeta members. Nodal genes, which have been identified in numerous vertebrate species, are expressed in specific cell types and tissues during embryonic development. Nodal signal transduction has been shown to play a pivotal role in inducing and patterning mesoderm and endoderm, and in regulating neurogenesis and left-right axis asymmetry. Antagonists, which act at different steps in the Nodal signal transduction pathway, have been shown to tightly modulate the inductive activity of Nodal.
- Publication
Cellular and molecular life sciences : CMLS, 2006, Vol 63, Issue 6, p672
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-005-5503-7