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- Title
The Wiskott-Aldrich syndrome.
- Authors
Orange, J S; Stone, K D; Turvey, S E; Krzewski, K
- Abstract
The Wiskott-Aldrich Syndrome (WAS) is an inherited immunodeficiency caused by a variety of mutations in the gene encoding the WAS protein (WASp). WASp is expressed in hematopoetic cells and facilitates the reorganization of the actin cytoskeleton in response to many important cell stimuli. Extensive study of WAS and more recently WASp has given great insight into the relevance of this molecule and related molecules to both basic cell biology and human immune defenses.
- Publication
Cellular and molecular life sciences : CMLS, 2004, Vol 61, Issue 18, p2361
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-004-4086-z