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- Title
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.
- Authors
Arundine, M; Tymianski, M
- Abstract
Stroke and neurotrauma mediate neuronal death through a series of events that involve multiple interdependent molecular pathways. It has been suggested that these pathways are triggered following elevations in extracellular excitatory amino acids, primarily glutamate [1]. This report outlines mechanisms involving glutamate-mediated excitotoxicity with specific focus on (i) the role of Ca(2+) in neurotoxicity, (ii) The concept of 'source specificity' of neurotoxicity, (iii) the role of the ionotropic N-methyl-D-aspartate (NMDA)-subtype glutamate receptor and its associated submembrane molecules that may give rise to signaling specificity in excitotoxicity and (iv) the role of glutamate-mediated free-radical generation and associated cell death pathways. We also highlight a novel, peptide-based approach for uncoupling NMDA receptors from excitotoxicity in the rat central nervous system subjected to focal ischemia, thereby reducing stroke infarct volume and improving neurological functioning.
- Publication
Cellular and molecular life sciences : CMLS, 2004, Vol 61, Issue 6, p657
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/s00018-003-3319-x