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- Title
CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes.
- Authors
Kim, Jong R; Horton, Nathan C; Mathew, Stephen O; Mathew, Porunelloor A
- Abstract
CS1 (CRACC, CD319, SLAMF7) is a member of the Signaling Lymphocyte Activation Molecule family expressed on immune cells mediating host defense. CS1 is a self-ligand and has both activating and inhibitory functions in Natural Killer cells. However, the function of CS1 in human monocytes is currently unknown. The objective of this study was to evaluate the control of CS1 surface expression in activated monocytes and to assess the effect of CS1 triggering on proinflammatory cytokine production by monocytes.
- Publication
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013, Vol 62, Issue 8, p765
- ISSN
1420-908X
- Publication type
Journal Article
- DOI
10.1007/s00011-013-0632-1