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- Title
The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis.
- Authors
Rosenzweig, Holly L; Woods, April; Clowers, Jenna S; Planck, Stephen R; Rosenbaum, James T
- Abstract
The inflammasome complex involving caspase-1 and nucleotide-binding domain, leucine-rich repeat containing protein (NLRP)3, also known as NALP3 or cryopyrin is important for host responses to microbial pathogens and several autoinflammatory diseases. We investigated the extent to which NLRP3 and caspase-1 control ocular interleukin (IL)-1β production and severity of uveitis (intraocular inflammatory disease) in an established, acute inflammatory uveitis model, endotoxin-induced uveitis (EIU).
- Publication
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Vol 61, Issue 3, p225
- ISSN
1420-908X
- Publication type
Journal Article
- DOI
10.1007/s00011-011-0404-8