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- Title
Adoptive T-cell immunotherapy of cancer using chimeric antigen receptor-grafted T cells.
- Authors
Davies, David Marc; Maher, John
- Abstract
Harnessing the power of the immune system to target cancer has long been a goal of tumor immunologists. One avenue under investigation is the modification of T cells to express a chimeric antigen receptor (CAR). Expression of such a receptor enables T-cell specificity to be redirected against a chosen tumor antigen. Substantial research in this field has been carried out, incorporating a wide variety of malignancies and tumor-associated antigens. Ongoing investigations will ensure this area continues to expand at a rapid pace. This review will explain the evolution of CAR technology over the last two decades in addition to detailing the associated benefits and disadvantages. The outcome of recent phase I clinical trials and the impact that these have had upon the direction of future research in this field will also be addressed.
- Publication
Archivum immunologiae et therapiae experimentalis, 2010, Vol 58, Issue 3, p165
- ISSN
1661-4917
- Publication type
Journal Article
- DOI
10.1007/s00005-010-0074-1