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- Title
Biodegradability of inhaled p-aramid respirable fibre-shaped particulates: representative of other synthetic organic fibre-types?
- Authors
Warheit, D B; Hartsky, M A; Webb, T R
- Abstract
Biopersistence, or alternatively, biodegradability (i.e., low biopersistence) represents an important concept in fibre toxicology. The studies described below were undertaken to investigate the mechanisms through which inhaled para-aramid (p-aramid) respirable, fibre-shaped particulates (RFP) are biodegraded in the lungs of exposed rats and hamsters; in contrast, cellulose fibres, another organic fibre-type, are known to be biopersistent. To investigate the mechanisms of RFP biodegradation, we have hypothesized that lung fluids activate p-aramid RFP following deposition, and the RFP are then vulnerable to enzymatic attack in the lungs.
- Publication
International archives of occupational and environmental health, 2000, Vol 73 Suppl, pS75
- ISSN
0340-0131
- Publication type
Journal Article
- DOI
10.1007/pl00014630