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- Title
Endogenous nitric oxide and endothelin-1 in persistent pulmonary hypertension of the newborn.
- Authors
Endo, A; Ayusawa, M; Minato, M; Takada, M; Takahashi, S; Harada, K
- Abstract
We studied changes in endogenous nitric oxide (NO) synthesis and endothelin-1 (ET-1) production in infants with persistent pulmonary hypertension of the newborn (PPHN). We determined concentrations of serum NO metabolites, i.e., nitrites and nitrates (NOx), and of plasma ET-1 in five infants with PPHN (PPHN group) and in 25 healthy full-term neonates (control group). In both groups, serum NOx concentrations increased over time and plasma ET-1 concentrations decreased with age. The differences in serum NOx concentrations between groups were not significant at < 12 h and 24 h of age; however, they were significantly higher in the PPHN group than in the control group at 5 days of age. The differences in plasma ET-1 concentrations between groups were not significant at 5 days of age, but were significantly higher in the PPHN group than in the control group at < 12 h and 24 h of age.
- Publication
European journal of pediatrics, 2001, Vol 160, Issue 4, p217
- ISSN
0340-6199
- Publication type
Journal Article
- DOI
10.1007/pl00008431