We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular genetic analysis of the calcineurin signaling pathways.
- Authors
Sugiura, R; Sio, S O; Shuntoh, H; Kuno, T
- Abstract
Calcineurin is a Ca2+- and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the powerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T cell activation, muscle hypertrophy, memory development, glucan synthesis, ion homeostasis, and cell cycle control. Notably, specific transcription factors have been shown to play a key role in regulating these functions, and their calcineurin-mediated dephosphorylation and nuclear translocation appear to be a central event in the signal transduction pathways. This review focuses on recent progress in these areas and discusses the evidence for cross-talk between calcineurin and other signaling pathways.
- Publication
Cellular and molecular life sciences : CMLS, 2001, Vol 58, Issue 2, p278
- ISSN
1420-682X
- Publication type
Journal Article
- DOI
10.1007/PL00000855