We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Natural inhibitors of cholinesterases: implications for adverse drug reactions.
- Authors
Krasowski, M D; McGehee, D S; Moss, J
- Abstract
Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. The solanaceous glycoalkaloids (SGAs) are naturally occurring steroids in potatoes and related plants that inhibit both acetylcholinesterase and butyrylcholinesterase. There are many clinical examples of direct SGA toxicity due to cholinesterase inhibition. The aim of this study was to review the hypotheses that (1) SGAs may be the evolutionary driving force for atypical butyrylcholinesterase alleles and that (2) SGAs may adversely influence the actions of anaesthetic drugs that are metabolized by acetylcholinesterase and butyrylcholinesterase.
- Publication
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Vol 44, Issue 5 Pt 1, p525
- ISSN
0832-610X
- Publication type
Journal Article
- DOI
10.1007/BF03011943