We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Stavudine-associated peripheral neuropathy in zidovudine-naïve patients: effect of stavudine exposure and antiretroviral experience.
- Authors
Scarsella, Anthony; Coodley, Gregg; Shalit, Peter; Anderson, Roger; Fisher, Robin L; Liao, Qiming; Ross, Lisa L; Hernandez, Jaime E
- Abstract
A post hoc analysis of safety data from study protocol NZT40012 assessed the incidence of conditions defined by the Centers for Disease Control and Prevention in 86 zidovudine-naïve, antiretroviral-experienced patients with HIV-1 infection who responded poorly (plasma HIV-1 RNA > 1000 copies/mL) despite at least 4 months' treatment with stavudine-containing regimens. Peripheral neuropathy occurred in 21%; other conditions were seen less frequently (candidiasis [13%], herpes zoster [12%], diarrhea lasting > 1 month [9%], Pneumocystis carinii pneumonia [9%], and wasting syndrome [8%]). The incidence of peripheral neuropathy rose significantly with the number of drugs comprising treatment regimens (> or = 4 vs 1-3; P = .013) and tended to be higher in patients with longer exposure to stavudine (29% with > or = 24 months' exposure vs 13% with < 24 months). Because peripheral neuropathy was observed with such high frequency, vigilance for signs and symptoms of this condition appears warranted if stavudine-containing regimens are to be continued.
- Publication
Advances in therapy, 2002, Vol 19, Issue 1, p1
- ISSN
0741-238X
- Publication type
Journal Article
- DOI
10.1007/BF02850013