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- Title
Artificial spores: cytocompatible encapsulation of individual living cells within thin, tough artificial shells.
- Authors
Yang, Sung Ho; Hong, Daewha; Lee, Juno; Ko, Eun Hyea; Choi, Insung S
- Abstract
Cells are encapsulated individually within thin and tough shells in a cytocompatible way, by mimicking the structure of bacterial endospores that survive under hostile conditions. The 3D 'cell-in-shell' structures-coined as 'artificial spores'-enable modulation and control over cellular metabolism, such as control of cell division, resistance to external stresses, and surface-functionalizability, providing a useful platform for applications, including cell-based sensors, cell therapy, regenerative medicine, as well as for fundamental studies on cellular metabolism at the single-cell level and cell-to-cell communications. This Concept focuses on chemical approaches to single-cell encapsulation with artificial shells for creating artificial spores, including cross-linked layer-by-layer assembly, bioinspired mineralization, and mussel-inspired polymerization. The current status and future prospects of this emerging field are also discussed.
- Publication
Small (Weinheim an der Bergstrasse, Germany), 2013, Vol 9, Issue 2, p178
- ISSN
1613-6829
- Publication type
Journal Article
- DOI
10.1002/smll.201202174