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- Title
Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation.
- Authors
Fadel, Tarek R; Li, Nan; Shah, Smith; Look, Michael; Pfefferle, Lisa D; Haller, Gary L; Justesen, Sune; Wilson, Corey J; Fahmy, Tarek M
- Abstract
Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.
- Publication
Small (Weinheim an der Bergstrasse, Germany), 2013, Vol 9, Issue 5, p666
- ISSN
1613-6829
- Publication type
Journal Article
- DOI
10.1002/smll.201201684