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- Title
Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.
- Authors
Shvedova, Anna A; Tkach, Alexey V; Kisin, Elena R; Khaliullin, Timur; Stanley, Shyla; Gutkin, Dmitriy W; Star, Alexander; Chen, Yanan; Shurin, Galina V; Kagan, Valerian E; Shurin, Michael R
- Abstract
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
- Publication
Small (Weinheim an der Bergstrasse, Germany), 2013, Vol 9, Issue 9-10, p1691
- ISSN
1613-6829
- Publication type
Journal Article
- DOI
10.1002/smll.201201470