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- Title
Analysis of the biochemical role of Lys-11 in polyubiquitin chain formation using quantitative mass spectrometry.
- Authors
Jung, Jin Woo; Bae, Sung Jun; Kang, Gum-Yong; Kim, Kyun-Hwan; Yeo, Woon-Seok; Park, Sang-Hyun; Seol, Jae Hong; Yi, Eugene C; Kim, Kwang Pyo
- Abstract
Protein ubiquitination plays a critical role in regulating many cellular events, such as protein localization and stability, cellular signal transduction and DNA repair. Recent studies have shown that polyubiquitin (polyUb) chains elongate through heterogeneous isopeptide linkages to K11, K29, K48 and K63. In this study we have investigated the usage of isopeptide linkages of polyUb chains in different molecular weight regions by using quantitative mass spectrometry.
- Publication
Rapid communications in mass spectrometry : RCM, 2013, Vol 27, Issue 2, p339
- ISSN
1097-0231
- Publication type
Journal Article
- DOI
10.1002/rcm.6447