We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases.
- Authors
O'Hurley, Gillian; Prencipe, Maria; Lundon, Dara; O'Neill, Amanda; Boyce, Susie; O'Grady, Anthony; Gallagher, William M; Morrissey, Colm; Kay, Elaine W; Watson, R William G
- Abstract
Castration-resistant prostate cancer (CRPC) represents a challenge to treat with no effective treatment options available. We recently identified serum response factor (SRF) as a key transcription factor in an in vitro model of castration resistance where we showed that SRF inhibition resulted in reduced cellular proliferation. We also demonstrated an association between SRF protein expression and CRPC in a cohort of castrate-resistant transurethral resections of the prostate (TURPS). The mechanisms regulating the growth of CRPC bone and visceral metastases have not been explored in depth due to the paucity of patient-related material available for analysis. In this study, we aim to evaluate SRF protein expression in prostate cancer (PCa) metastases, which has not previously been reported.
- Publication
The Prostate, 2014, Vol 74, Issue 3, p306
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.22752