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- Title
Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells.
- Authors
Zhang, Shumin; Wang, Yanru; Chen, Zhengjia; Kim, Sungjin; Iqbal, Shareen; Chi, Andrew; Ritenour, Chad; Wang, Yongqiang A; Kucuk, Omer; Wu, Daqing
- Abstract
Cabazitaxel (Jevtana) has been approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). However, most patients progress and become chemoresistant, which remains a major challenge in the management of advanced PCa. In this study, we investigated whether genistein, an isoflavone abundant in soy products, could sensitize mCRPC cells to cabazitaxel treatment in experimental models.
- Publication
The Prostate, 2013, Vol 73, Issue 15, p1681
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.22705