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- Title
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
- Authors
Lovaas, Jenna D; Zhu, Lijia; Chiao, Christine Y; Byles, Vanessa; Faller, Douglas V; Dai, Yan
- Abstract
Matrix metalloproteinase-2 (MMP2) has been shown to play an important role in cancer cell invasion and the expression of MMP2 is associated with the poor prognosis of prostate cancer; however, the mechanism of MMP2 expression is largely unknown. SIRT1 is a nicotinamide adenine dinucleotide-dependent histone deacetylase (class III HDAC) that has recently been shown to have implications in regulating cancer cell growth and apoptosis. The purpose of this study is to determine the role of SIRT1 in regulating MMP2 expression and tumor invasion in prostate cancer cells.
- Publication
The Prostate, 2013, Vol 73, Issue 5, p522
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.22592