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- Title
Null genotypes at the GSTM1 and GSTT1 genes and the risk of benign prostatic hyperplasia: a case-control study and a meta-analysis.
- Authors
Choubey, Vimal Kumar; Sankhwar, Satya Narayan; Tewari, Reshu; Sankhwar, Pushplata; Singh, Bhupendra Pal; Rajender, Singh
- Abstract
Benign prostatic hyperplasia (BPH) is an age related non-malignant disease diagnosed as lower urinary tract symptoms and prostatic enlargement. Null genotypes in drug detoxification glutathione-S-transferase genes/enzymes, such as GSTT1 and GSTM1 have been reported to increase risk of several cancers including prostate. Meta-analysis on PC also suggested significant impact of GSTM1 null genotype but not that of GSTT1; however, BPH data have not been subjected to meta-analysis.
- Publication
The Prostate, 2013, Vol 73, Issue 2, p146
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.22549