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- Title
Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models.
- Authors
Ateeq, Bushra; Vellaichamy, Adaikkalam; Tomlins, Scott A; Wang, Rui; Cao, Qi; Lonigro, Robert J; Pienta, Kenneth J; Varambally, Sooryanarayana
- Abstract
Androgens play a crucial role in prostate cancer, hence the androgenic pathway has become an important target of therapeutic intervention. Previously we discovered that gene fusions between the 5'-untranslated region of androgen regulated gene TMPRSS2 and the ETS transcription factor family members were present in a majority of the prostate cancer cases. The resulting aberrant overexpression of ETS genes drives tumor progression.
- Publication
The Prostate, 2012, Vol 72, Issue 14, p1542
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.22509