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- Title
Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
- Authors
Ray, Manisha; Hostetter, Daniel R; Loeb, Carly R K; Simko, Jeffry; Craik, Charles S
- Abstract
In order for tumors to grow and proliferate, they must avoid recognition by immune cells and subsequent death by apoptosis. Granzyme B (GrB), a protease located in natural killer cells, initiates apoptosis in target cells. Inhibition of GrB by PI-9, its natural inhibitor, can prevent apoptosis. Here we investigate whether PI-9 protects prostate cancer cells from apoptosis.
- Publication
The Prostate, 2012, Vol 72, Issue 8, p846
- ISSN
1097-0045
- Publication type
Journal Article
- DOI
10.1002/pros.21486