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Title
Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model.
Authors
Bruno, Tullia C; Rothwell, Cristin; Grosso, Joseph F; Getnet, Derese; Yen, Hung Rong; Durham, Nicholas M; Netto, George; Pardoll, Drew M; Drake, Charles G
Abstract
The CD8 T-cell response to prostate and other cancers is often functionally diminished or absent. This may occur via deletion of tumor-specific T cells, through acquisition of an anergic phenotype, or via active suppression mediated by another population of cells.