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- Title
Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia.
- Authors
Kumar, Kirthi R; Koduru, Prasad; Timmons, Charles; Monaghan, Sara; Cavalier, Maryellen; Luu, Hung S
- Abstract
Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML.
- Publication
Pediatric blood & cancer, 2013, Vol 60, Issue 11, pE146
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.24645