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- Title
GDF15-mediated upregulation of ferroportin plays a key role in the development of hyperferritinemia in children with hemophagocytic lymphohistiocytosis.
- Authors
Wu, Jian-Rong; Yuan, Li-Xing; Ma, Zhi-Gui; Chen, Xiao-Xi; Gu, Ling; Gao, Ju
- Abstract
Growth differentiation factor 15 (GDF15), a divergent TGFβ superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes. However, little is known about possible roles that GDF15 might play in the regulation of iron homeostasis and development of hyperferritinemia in children with hemophagocytic lymphohistiocytosis (HLH).
- Publication
Pediatric blood & cancer, 2013, Vol 60, Issue 6, p940
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.24373