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- Title
SIX1 protein expression selectively identifies blastemal elements in Wilms tumor.
- Authors
Sehic, Daniel; Karlsson, Jenny; Sandstedt, Bengt; Gisselsson, David
- Abstract
Wilms tumor (WT) is the most common renal neoplasm in children. Histologically, most WTs consist of three tissue elements: blastema, epithelium, and stroma. Some cases also show diffuse or focal anaplastic features. Previous studies have shown that a predominance of blastemal cells in post-chemotherapy WT specimens is associated with a poor clinical course. However, there is currently no molecular marker for blastemal cells, and risk stratification for post-nephrectomy treatment is therefore often based on clinico-histological parameters alone.
- Publication
Pediatric blood & cancer, 2012, Vol 59, Issue 1, p62
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.24025