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- Title
Cell cycle-specific function of Ikaros in human leukemia.
- Authors
Li, Zhanjun; Song, Chunhua; Ouyang, Hongsheng; Lai, Liangxue; Payne, Kimberly J; Dovat, Sinisa
- Abstract
The loss of Ikaros is associated with the development of B and T cell leukemia. Data on Ikaros function, including its role as a tumor suppressor and a regulator of cell cycle progression, come almost exclusively from murine studies; little is known of the mechanisms that regulate human Ikaros function. Our studies are the first to examine the function and regulation of human Ikaros isoforms during the cell cycle in human ALL.
- Publication
Pediatric blood & cancer, 2012, Vol 59, Issue 1, p69
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.23406