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- Title
Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.
- Authors
Wu, Jianqiang; Dombi, Eva; Jousma, Edwin; Scott Dunn, R; Lindquist, Diana; Schnell, Beverly M; Kim, Mi-Ok; Kim, Aerang; Widemann, Brigitte C; Cripe, Timothy P; Ratner, Nancy
- Abstract
Neurofibromatosis type 1 (NF1) is an inherited disease predisposing affected patients to variable numbers of benign neurofibromas. To date there are no effective chemotherapeutic drugs available for this slow growing tumor. Molecularly targeted agents that aim to slow neurofibroma growth are being tested in clinical trials. So preclinical models for testing potential therapies are urgently needed to prioritize drugs for clinical trials of neurofibromas.
- Publication
Pediatric blood & cancer, 2012, Vol 58, Issue 2, p173
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.23015