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- Title
Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.
- Authors
Houghton, Peter J; Gorlick, Richard; Kolb, E Anders; Lock, Richard; Carol, Hernan; Morton, Christopher L; Keir, Stephen T; Reynolds, C Patrick; Kang, Min H; Phelps, Doris; Maris, John M; Billups, Catherine; Smith, Malcolm A
- Abstract
AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent translation through the mTORC1 complex and Akt activation through the mTORC2 complex. Procedures AZD8055 was tested against the PPTP in vitro panel at concentrations ranging from 1.0 nM to 10 µM and against the PPTP in vivo panels at a dose of 20 mg/kg administered orally daily x 7 for 4 weeks.
- Publication
Pediatric blood & cancer, 2012, Vol 58, Issue 2, p191
- ISSN
1545-5017
- Publication type
Journal Article
- DOI
10.1002/pbc.22935