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- Title
Accumulation of micron sized iron oxide particles in endothelin-1 induced focal cortical ischemia in rats is independent of cell migration.
- Authors
Granot, Dorit; Shapiro, Erik M
- Abstract
Endogenous labeling of stem/ progenitor cells via intracerebroventricular injection of micron-sized particles of iron oxide (MPIOs) has become standard methodology for MRI of adult neurogenesis. While this method is well characterized in the naïve rodent brain, it has not been fully investigated in disease models. Here, we describe methodological challenges that can confound data analysis when this technique is applied to a rat model of stroke, the endothelin-1 model of focal cortical ischemia.
- Publication
Magnetic resonance in medicine, 2014, Vol 71, Issue 4, p1568
- ISSN
1522-2594
- Publication type
Journal Article
- DOI
10.1002/mrm.24788