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- Title
Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.
- Authors
Wang, Sumin; Wu, Jiangping; Hu, Lingmin; Ding, Chenyue; Kan, Yanjing; Shen, Yan; Chen, Xiaojun; Shen, Hongbing; Guo, Xirong; Hu, Zhibin
- Abstract
Single-nucleotide polymorphisms (SNPs) of TERT rs2736098, rs2736100, and CLPTM1L rs402710 at 5p15.33 are significantly associated with risk of a spectrum of cancers. However, cervical cancer has been rarely evaluated. In this study, we genotyped the three SNPs in a case-control study with 1,033 cervical cancer cases and 1,053 cancer-free controls in a Chinese population. Logistic regression analyses showed that the two TERT SNPs both significantly associated with cervical cancer risk in the recessive model (rs2736098, AA vs.
- Publication
Molecular carcinogenesis, 2012, Vol 51 Suppl 1, pE118
- ISSN
1098-2744
- Publication type
Journal Article
- DOI
10.1002/mc.21872