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- Title
Star-Shaped Polymer Consisting of a Porphyrin Core and Poly( L-lysine) Dendron Arms: Synthesis, Drug Delivery, and In Vitro Chemo/Photodynamic Therapy.
- Authors
Zhou, Xiao-Yan; Shi, Yun-Feng; Zhang, Yi; Xue, Wei; Lin, Jian-Tao; Ma, Dong; Liu, Zong-Hua; Zheng, Qian-Qian
- Abstract
A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by the click reaction between azido-modified porphyrin and propargyl focal point poly(L-lysine) dendrons. Its chemical structure is characterized by 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μg mg−1. By in vitro toxicity assay, PP-PLLD has no dark cytotoxicity but has significant phototoxicity. Moreover, DOX-loaded PP-PLLD shows a higher cytotoxicity under the light condition than PP-PLLD or DOX alone, suggesting PP-PLLD has a potential application in combined photodynamic therapy and chemotherapy.
- Publication
Macromolecular Rapid Communications, 2013, Vol 34, Issue 6, p548
- ISSN
1022-1336
- Publication type
Academic Journal
- DOI
10.1002/marc.201200742