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- Title
Calcium-mediated secondary cross-linking of bisphosphonated oligo(poly(ethylene glycol) fumarate) hydrogels.
- Authors
Nejadnik, M Reza; Yang, Xia; Mimura, Tokio; Birgani, Zeinab Tahmasebi; Habibovic, Pamela; Itatani, Kiyoshi; Jansen, John A; Hilborn, Jons; Ossipov, Dmitri; Mikos, Antonios G; Leeuwenburgh, Sander C G
- Abstract
This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.
- Publication
Macromolecular bioscience, 2013, Vol 13, Issue 10, p1308
- ISSN
1616-5195
- Publication type
Journal Article
- DOI
10.1002/mabi.201300117