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- Title
Preparation of pixantrone/poly(γ-glutamic acid) nanoparticles through complex self-assembly for oral chemotherapy.
- Authors
Meng, Lili; Ji, Bing; Huang, Wei; Wang, Dali; Tong, Gangsheng; Su, Yue; Zhu, Xinyuan; Yan, Deyue
- Abstract
A facile and green approach is reported to construct pixantrone/poly(γ-glutamic acid) nanoparticles (PIX/γ-PGA NPs) as an oral drug delivery system through the complex self-assembly of polyelectrolyte γ-PGA and the anticancer drug pixantrone dimaleate (PDM). The complex self-assembly behavior is investigated in detail. The results demonstrate that PDM can interact with γ-PGA to conveniently form NPs and the size of NPs can be controlled by adjusting the solution volume ratio of PDM to γ-PGA. These NPs illustrate their pH-dependent release behavior, efficient cellular uptake and enhanced drug efficacy through an in vitro release study, flow cytometry, CLSM analysis and the MTT assay. In summary, PIX/γ-PGA NPs may serve as a promising oral drug delivery system for cancer therapy.
- Publication
Macromolecular bioscience, 2012, Vol 12, Issue 11, p1524
- ISSN
1616-5195
- Publication type
Journal Article
- DOI
10.1002/mabi.201200137