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- Title
A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque.
- Authors
Phipps, Jennifer E; Sun, Yinghua; Fishbein, Michael C; Marcu, Laura
- Abstract
This study describes a novel fluorescence lifetime imaging (FLIM) classification method to determine the ratio of collagen to lipid content in the fibrous cap of atherosclerotic plaques. Additionally, an analytical process to assess risk of plaque rupture based on this ratio is proposed. Collagen to lipid ratio has been shown to be an important parameter to evaluate structural integrity of the fibrous cap. FLIM and other time-resolved fluorescence techniques have recently been applied to the study of atherosclerosis based on the ability to assess biochemical composition.
- Publication
Lasers in surgery and medicine, 2012, Vol 44, Issue 7, p564
- ISSN
1096-9101
- Publication type
Journal Article
- DOI
10.1002/lsm.22059