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- Title
Human papillomavirus in oropharyngeal squamous cell carcinoma: assessing virus presence in normal tissue and activity in cervical metastasis.
- Authors
Laborde, Rebecca R; Janus, Jeffrey R; Olsen, Steven M; Wang, Vivian W; Garcia, Joaquin J; Graham, Rondell P; Moore, Eric J; Olsen, Kerry D; Kasperbauer, Jan L; Price, Daniel L; Berres, Michael; Halling, Geoffrey; Smith, David I
- Abstract
Human papillomavirus (HPV) has been established as an etiologic and prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC). HPV oncogenesis involves expression of E6/E7 oncoproteins, with downstream p53 degradation and pRb inhibition. Although much research has focused on HPV's oncogenic behavior in primary OPSCC, minimal information exists about HPV in adjacent normal and metastatic tissue.
- Publication
The Laryngoscope, 2012, Vol 122, Issue 12, p2707
- ISSN
1531-4995
- Publication type
Journal Article
- DOI
10.1002/lary.23516