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- Title
Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations.
- Authors
Lennon, Christen J; Birkeland, Andrew C; Nuñez, José Arturo Pacheco; Su, Gloria H; Lanzano, Patricia; Guzman, Edwin; Celis, Katrina; Eisig, Sidney B; Hoffman, David; Rendon, Maria Teresa Guerra; Ostos, Henry; Chung, Wendy K; Haddad, Joseph, Jr
- Abstract
Orofacial clefts are the most common craniofacial birth defects in humans, with the majority of orofacial clefts occurring as nonsyndromic cleft lip with or without cleft palate (NSCLP). We previously demonstrated associations between single-nucleotide polymorphisms (SNPs) in the IRF6 gene and NSCLP in the Honduran population. Here we investigated other candidate genes and chromosomal regions associated with NSCLP identified from genome-wide association studies (GWAS), including MAFB, ABCA4, 8q24, 9q22, 10q25, and 17q22 in two independent Hispanic populations.
- Publication
The Laryngoscope, 2012, Vol 122, Issue 9, p2082
- ISSN
1531-4995
- Publication type
Journal Article
- DOI
10.1002/lary.23394