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- Title
Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq.
- Authors
Calohan, Jess; Peterson, Kris; Peskind, Elaine R; Raskind, Murray A
- Abstract
Trauma nightmares and sleep disturbance impair combat soldiers' functioning. The alpha-1 adrenoreceptor antagonist prazosin has been demonstrated effective for these symptoms in Vietnam veterans. Thirteen soldiers seeking relief from distressing trauma nightmares impairing military function in northern Iraq in 2006 received prazosin alone or in combination with other psychotropics. Mean prazosin dose was 4.1 (SD = 2.2) mg before bed. Six soldiers improved markedly and 3 moderately on the Clinical Global Impression of Change Ratings of distressing dreams decreased from an average of 7.0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 6.7 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment.
- Publication
Journal of traumatic stress, 2010, Vol 23, Issue 5, p645
- ISSN
1573-6598
- Publication type
Journal Article
- DOI
10.1002/jts.20570