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- Title
Translational advances regarding hereditary breast cancer syndromes.
- Authors
Gage, M; Wattendorf, D; Henry, L R
- Abstract
Approximately 5-10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non-BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing and interpretations.
- Publication
Journal of surgical oncology, 2012, Vol 105, Issue 5, p444
- ISSN
1096-9098
- Publication type
Journal Article
- DOI
10.1002/jso.21856