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- Title
Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation.
- Authors
KonićRistić, Aleksandra; SrdićRajić, Tatjana; Kardum, Nevena; AleksićVeličković, Vesna; Kroon, Paul A; Hollands, Wendy J; Needs, Paul W; Boyko, Nadiya; Hayran, Osman; Jorjadze, Mariam; Glibetić, Maria
- Abstract
BACKGROUND The beneficial effect of fruit- and vegetable-rich diets on cardiovascular health is partly attributed to the effect of their bioactive compounds on platelet function. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples from healthy subjects ( n = 4) and subjects with metabolic syndrome ( n = 4) were treated with six extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Markers of arachidonic acid induced platelet activation and platelet-leucocyte aggregation were assessed using flow cytometry. RESULTS In subjects with metabolic syndrome, kale extract significantly inhibited agonist induced P-selectin expression ( P = 0.004). Sulforaphane-cysteine-glycine, a human plasma metabolite of the related glucosinolate, glucoraphanin, significantly inhibited P-selectin and GPIIb-IIIa expression ( P = 0.020 and 0.024, respectively) and platelet-neutrophil aggregation ( P = 0.027). Additionally, pomegranate extract significantly inhibited GPIIb-IIIa expression ( P = 0.046) in subjects with metabolic syndrome. In healthy subjects only dill extract significantly inhibited agonist induced P-selectin expression ( P = 0.025). CONCLUSION These data show that bioactive-rich extracts of kale and pomegranate that are consumed as traditional plant foods of Black Sea area countries were effective in modulating platelet function. © 2013 Society of Chemical Industry
- Publication
Journal of the Science of Food & Agriculture, 2013, Vol 93, Issue 14, p3581
- ISSN
0022-5142
- Publication type
Academic Journal
- DOI
10.1002/jsfa.6328