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- Title
Low-level laser therapy in collagenase-induced Achilles tendinitis in rats: analyses of biochemical and biomechanical aspects.
- Authors
Marcos, Rodrigo Labat; Leal-Junior, Ernesto Cesar Pinto; Arnold, Gilles; Magnenet, Vincent; Rahouadj, Rachid; Wang, Xiong; Demeurie, Frank; Magdalou, Jacques; de Carvalho, Maria Helena Catelli; Lopes-Martins, Rodrigo Álvaro Brandão
- Abstract
NSAIDs are widely prescribed and used over the years to treat tendon injuries despite its well-known long-term side effects. In the last years several animal and human trials have shown that low-level laser therapy (LLLT) presents modulatory effects on inflammatory markers, however the mechanisms involved are not fully understood. The aim of this study was to evaluate the short-term effects of LLLT or sodium diclofenac treatments on biochemical markers and biomechanical properties of inflamed Achilles tendons. Wistar rats Achilles tendons (n = 6/group) were injected with saline (control) or collagenase at peritendinous area of Achilles tendons. After 1 h animals were treated with two different doses of LLLT (810 nm, 1 and 3 J) at the sites of the injections, or with intramuscular sodium diclofenac. Regarding biochemical analyses, LLLT significantly decreased (p < 0.05) COX-2, TNF-α, MMP-3, MMP-9, and MMP-13 gene expression, as well as prostaglandin E(2) (PGE(2) ) production when compared to collagenase group. Interestingly, diclofenac treatment only decreased PGE(2) levels. Biomechanical properties were preserved in the laser-treated groups when compared to collagenase and diclofenac groups. We conclude that LLLT was able to reduce tendon inflammation and to preserve tendon resistance and elasticity.
- Publication
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012, Vol 30, Issue 12, p1945
- ISSN
1554-527X
- Publication type
Journal Article
- DOI
10.1002/jor.22156